5 edition of Effects of therapy on biology and kinetics of the residual tumor found in the catalog.
Includes bibliographical references and index.
|Statement||editors, Joseph Ragaz ... [et al.].|
|Series||Progress in clinical and biological research ;, v. 354B|
|Contributions||Ragaz, J. 1945-|
|LC Classifications||RC270.8 .I534 1989|
|The Physical Object|
|Pagination||v. <2 > :|
|LC Control Number||90012358|
Some cancer treatments, such as those listed below, may cause urinary and bladder problems. Radiation therapy to the pelvis (including reproductive organs, the bladder, colon and rectum) can irritate the bladder and urinary problems often start several weeks after radiation therapy begins and go away several weeks after treatment has been completed. Tumor progression is challenged by numerous intrinsic and extrinsic bottlenecks that can hold the tumor in dormant stages for prolonged periods. Given the complex, multiscale nature of these bottlenecks, the Center of Cancer Systems Biology organized a workshop on critical issues of systems biology of tumor by:
Radiation therapy (also called radiotherapy, X-ray therapy, or irradiation) is the use of ionizing radiation to kill cancer cells and shrink tumors. Radiation therapy can be administered externally via external beam radiotherapy (EBRT) or internally via effects of radiation therapy are localised and confined to the region being lty: oncology. lowing treatment. The kinetics of breast cancer recurrence, which may occur up to 25 years after treatment of the primary tumor, imply that at least some breast cancers pass through a phase of dormancy prior to relapse (2–5). While the vast majority of tumor cells are typically eliminated.
The function f is the growth rate of the malignant dividing cell and depends on both the total volume of actively dividing cells, V T, and the tumor vascular volume, V function g is the transition rate of the dividing cells to the non-dividing cells under the influence of radiation. Both f and g are a function of dose second term in Equation indicates that the non Cited by: Estimate and compare the response of residual tumor and the incidence and severity of structural, physiological, and vascular effects of normal brain in children and young adults with ependymoma after treatment with a second course of irradiation using specific methods of diffusion, contrast-enhancement, magnetization transfer, vascular and.
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Prog Clin Biol Res. ;B Effects of therapy on biology and kinetics of the residual tumor, Part B: clinical aspects. Proceedings of an international symposium. Prog Clin Biol Res.
;A Effects of therapy on biology and kinetics of the residual tumor, Part A: pre-clinical aspects. Proceedings of an international symposium.
Get this from a library. Effects of therapy on biology and kinetics of the residual tumor: proceedings of an International Symposium on the Effects of Therapy on the Biology and Kinetics of the Surviving Tumor, held in Vancouver, British Columbia, Canada, February[J Ragaz;].
Get this from a library. Effects of therapy on biology and kinetics of the residual tumor: proceedings of an International Symposium on the Effects of Therapy on the Biology and Kinetics of the Surviving Tumor, held in Vancouver, British Columbia, Canada, February[J Ragaz; et al].
The development of assays for measuring the survival of tumor cells revolutionized expermental cancer therapy by enabling researchers to move from assessing the gross responses of cell cultures and tumors to measuring the survival of cells in the critical clonogenic tumor cell by: Norton L () Biology of residual breast cancer after therapy: A kinetic interpretation.
In: Ragaz J, Simpson-Herren L, Lippman ME, Fisher B (eds) Effects of therapy on biology and kinetics of the residual tumor, part A: preclinical aspects. Wiley-Liss, New York, pp – Google ScholarCited by: The development of assays for measuring the survival of individual tumor cells revolutionized the study of experimental cancer therapy by enabling researchers to move from assessing the gross responses of tumors to measuring the survival of cells in the critical, clonogenic tumor-cell populations (1).
The development and use of these assays formed the basis for many of our modern concepts of tumor biology Cited by: 1. Prog Clin Biol Res. ;A Biology of residual breast cancer after therapy: a kinetic interpretation.
Norton L(1). Author information: (1)Memorial Sloan-Kettering Cancer Institute, New York, NY PMID:Cited by: 3. Experimental Study on the Growth and Proliferation Kinetics of Residual Tumor After Surgery in Mouse Neuroblastoma By Shuhei Ogita, Kazuaki Tokiwa, Yukikatu Goto, and Susumu Majima Japan In order to elucidate the proliferation kinetics of residual tumors after surgery, experimental studies were performed, using CNB and A/J mice, tumor-host by: 3.
Out of Warburg Effect: an effective cancer treatment targeting the tumor specific metabolism and dysregulated pH.
As stated by Otto Warburg nearly a century ago, cancer is a metabolic disease, a fermentation caused by malfunctioning mitochondria, resulting in increased anabolism and decreased catabolism.
The results of this study suggest that a mathematical model can create a virtual in silico tumor with the same growth kinetics as a particular patient and can not only predict treatment response.
Combination Therapy. Combination therapy is defined as disease treatment with two or more drugs to achieve efficacy with lower doses or lower toxicity drugs, chemosensitize cells so that an additional compound can be more potent, gain additive or synergistic effects, or combat expected acquired resistance or minimize the possibility for development of drug resistance.
Patients with brain tumors are vulnerable to wide ranging side effects from radiation therapy that are magnified in young children and enhanced by tumor and treatments preceding radiation therapy. Side effects range from treatable deficits that rarely impact long-term function to severe and debilitating side effects that result in the loss of functional by: The Third Edition of Gene Therapy of Cancer provides crucial updates on the basic and applied sciences of gene therapy.
It offers a comprehensive assessment of the field including the areas of suicide gene therapy, oncogene and suppressor gene targeting, immunotherapy, drug resistance gene therapy, and the genetic modification of stem cells.
Effects of the Biology of Tumor Growth. A major obstacle in the use of cancer chemotherapy is the fact that a tumor usually is far advanced before it is detected. For example, a tumor that is 1 cm in diameter contains about 10 9 cells. Another 10 doublings would produce 10 12 cells, a mass that might measure 20 cm.
A mass this size may be. achieved a complete remission, with the intent of delaying the regrowth of residual tumor cells. Adjuvant: A short course of high-dose, usually combination chemotherapy in a patient with no evidence of residual cancer after surgery or radiotherapy, given with the intent of destroying a low number of residual tumor Size: KB.
Radiation therapy has side effects because it not only kills or slows the growth of cancer cells, it can also affect nearby healthy cells. Many people who get radiation therapy experience fatigue. Other side effects depend on the part of the body that is being treated. Abstract. Using 32 P labelling and autoradiography, Howard and Pelc (1) demonstrated that DNA synthesis was relegated to a discrete phase (S-phase), temporally separated from mitosis by a post-synthetic gap (G2), and a post mitotic gap (G1).
The synthesis of [3 H]-thymidine in (2) provided a specific radiolabeled DNA precursor suitable for detailed studies of cell cycle : Paul G. Braunschweiger. Tumor growth modeling. Multiple methods of modeling the kinetics of tumor growth have been propoOne of the most popular models is exponential growth, which assumes the tumor can grow Cited by: Montalenti et al.
() simulated cancer-cell kinetics after drug treatment (in particular, the effects of cisplatin on ovarian carcinomas). Recently, Marcu et al. () also studied the biological effects of cisplatin and simulated the consequence of cisplatin resistance on tumor Cited by:.
Importantly, they extend this concept, highlighting the notion that tumor lineage may serve as a template, with MCL-1 inhibitors potentially being particularly useful for the treatment of RAF-MEK Author: Kris C.
Wood.The growth kinetics of clonogenic tumor cells that survive radiation therapy In: Effects of therapy on biology and kinetics of the residual tumor. Part B: clinical aspects Re Kallman.Systems Biology of Tumor Dormancy: Linking Biology and Mathematics on Multiple Scales to Improve Cancer Therapy Article (PDF Available) in Cancer Research 72(9) .